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The Effect of Gasoline Pretreatment in Diesel Toxicity of The Liver on Male Wistar Rats (Ratus Ratus)

	International Journal of Scientific Research and Engineering Development (IJSRED)	Full Text:
	Published Issue : Volume-4 Issue-1
	Year of Publication : 2021
	Unique Identification Number : IJSRED-V4I1P89
	Authors : EDET C.K, Dede E.B
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Abstract :

The inhalation route was used to assess the effects of gasoline pretreatment on diesel toxicity in rats. The intra-peritoneal LD50 of gasoline, inhalational LD50 of diesel and inhalational LD50 of diesel following intra-peritoneal gasoline pretreatment in rats were obtained at 186.2 g/kg, 684 g/kg and 342 g /kg body weight respectively. Rats pretreated with gasoline showed marked signs of toxicity that included respiratory distress, sedation, coma and death. Those exposed to gasoline and diesel only were less affected. Liver enzymology showed liver damage with increased liver enzyme activity (ALT, AST, ALP) in all treated groups, but the effects were more pronounced in the gasoline pretreated group. This study suggests an enhancement of the toxicity of diesel by gasoline.