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Organ Transplantation Methods and Major Reasons of Organ Rejection

	International Journal of Scientific Research and Engineering Development (IJSRED)
	Published Issue : Volume-3 Issue-4
	Year of Publication : 2020
	Unique Identification Number : IJSRED-V3I4P6
	Authors :Bahzad Ahmad Farhan, Jazeel Ur Rehman, Saba Maruiam, Sameen Mumtaz, Zirwa Anwar, Irha Basit

Bahzad Ahmad Farhan, Jazeel Ur Rehman, Saba Maruiam, Sameen Mumtaz, Zirwa Anwar, Irha Basit "Organ Transplantation Methods and Major Reasons of Organ Rejection" International Journal of Scientific Research and Engineering Development (IJSRED) Vol3-Issue4 | 36-50.

Abstract :

Organ transplantation is a surgical procedure in which damaged or diseased organ of recipient person is replaced with healthy organ of a donor from live or dead source. organ can be taken from donor up to 24 hours past the termination of heart and can be stored up to 5 years by maintaining the ideal conditions for organ. There are different types of organ transplantation which are auto transplantation, allotransplantation, isotranspalantation and xenotransplantation which are classified on the base of source of organ donor and organ receiver. In case of allotransplantation. In case of allotransplantation and xenotransplantation there are high risk of organ rejection because immune system of receiver does not allow the foreign organ to work properly because foreign organ have specific major histocompatibility complexes on their cell membrane and specific self-antigens recipient immune system recognize this organ as foreign pathogen and recipient immune system activated and show immune response against this foreign organ. Therefore, for allotransplantation and xenotransplantation some immune suppressant drugs are used before organ transplantation that suppress the recipient immune system and allow organ to work normally as original organ. In case of auto-transplantation as MHC and self-antigens are same so there are less chances of organ rejection. Organ transplantation increase the bioethical issues by illegal trading of organs which cause the socio-economic problems in the society and should be banned by the governments.

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