International Journal of Scientific Research and Engineering Development

Curcumin, a primary bioactive polyphenolic compound found in turmeric has been widely recognised for its potent anti-inflammatory activity. However, its therapeutic use is limited due to poor solubility and poor bioavailability. This study aims to formulate curcumin-loaded liposomes by using thin film hydration method with lecithin and cholesterol. The formulated curcumin liposomes were then evaluated for particle size, drug content, entrapment efficiency, In-vitro drug release and anti-inflammatory activity. In-vitro antiinflammatory activity was assessed by the protein denaturation inhibition method. The curcumin-loaded liposomes demonstrated satisfactory physicochemical properties and sustained release compared with plain curcumin. The study concludes that liposomal encapsulation can enhance the solubility and therapeutic performance of curcumin. Thus, curcumin-loaded liposomes may serve as a promising delivery system for improving its anti-inflammatory efficacy.

Syeda Ayesha Jameel, Mohammad Sameer Ansari,"Development and Evaluation of Curcumin-Loaded Liposomes for Anti-inflammatory Activity" International Journal of Scientific Research and Engineering Development, V9(3): Page(1009-1012) May-June 2026. ISSN: 2581-7175. www.ijsred.com. Published by Scientific and Academic Research Publishing.