International Journal of Scientific Research and Engineering Development

Alcohol Dependence Syndrome (ADS) is widely recognized as a chronic and relapsing disorder that is frequently accompanied by various forms of cognitive impairment. These cognitive difficulties may continue even after the immediate effects of alcohol intoxication have subsided and during the early phases of abstinence. Individuals with ADS commonly experience deficits in executive functioning, attention, working memory, and cognitive flexibility. Such impairments are generally linked to disturbances in the functioning of frontal and fronto-subcortical neural pathways of the brain. Depression is among the most frequently observed psychiatric comorbid conditions in individuals suffering from ADS. Independently, depression is also associated with slower cognitive processing, weakened executive functioning, and difficulties in effective information processing. When depressive symptoms occur simultaneously with Alcohol Dependence Syndrome, the combined effect may intensify cognitive dysfunction. This interaction may further lead to poor awareness of one’s condition, lower adherence to treatment procedures, and a greater likelihood of relapse. Despite these significant clinical implications, the extent to which depression influences or modifies cognitive functioning in individuals with ADS has not been sufficiently investigated in clinical populations.

Preethi SS,"Role of Depression in Modulating Cognitive Deficits in Alcohol Dependence Syndrome" International Journal of Scientific Research and Engineering Development, V9(2): Page(292-300) Mar-Apr 2026. ISSN: 2581-7175. www.ijsred.com. Published by Scientific and Academic Research Publishing.