International Journal of Scientific Research and Engineering Development

The jackfruit tree (Artocarpus integrifolia), a prominent species in the Moraceae family, is globally valued for its nutritious fruit and longstanding use in traditional medicine systems like Ayurveda. This review systematically consolidates current scientific evidence on its phytochemistry and therapeutic potential. Rich in diverse bioactive compounds including phenolics, flavonoids, tannins, lectins (jacalin), and prenylated flavonoids (artocarpin) jackfruit exhibits a broad spectrum of pharmacological activities. Its potent antioxidant capacity is linked to high polyphenol content, while antidiabetic effects are demonstrated through blood glucose regulation, improved insulin secretion, and inhibition of carbohydrate digestion. Antimicrobial properties are evident against various bacterial and fungal pathogens, with compounds like jacalin showing biofilm disruption and immune stimulation. Notably, extracts and purified compounds exhibit selective anticancer activity by inhibiting proliferation in breast, colon, and leukemia cell lines, inducing differentiation, and enhancing the efficacy of conventional chemotherapeutics. These multifaceted bioactivities validate its ethnomedicinal applications and underscore its potential as a source of safe, natural therapeutic agents. The findings highlight Artocarpus integrifolia as a promising, sustainable resource for developing nutraceuticals and complementary medicines. To fully realize this potential, future research must prioritize the isolation of novel compounds, detailed mechanistic studies, rigorous in vivo validation, and clinical trials to establish efficacy, dosage, and safety for pharmacological applications.

Fakeha Mohammed Rehan Shaikh, Ashish Sambhaji Uzgare,"A Review of the Phytochemistry, Biological Activities, and Therapeutic Prospects of Artocarpus integrifolia (Jackfruit)" International Journal of Scientific Research and Engineering Development, V9(2): Page(1115-1122) Mar-Apr 2026. ISSN: 2581-7175. www.ijsred.com. Published by Scientific and Academic Research Publishing.