International Journal of Scientific Research and Engineering Development

A sustainable and operationally simple methodology has been developed for the synthesis of 1,3,5- trisubstituted-2-pyrazolines through the cyclocondensation of substituted chalcones with hydrazine hydrate in the presence of magnetically separable cobalt ferrite (CoFe₂O₄) nanoparticles as a heterogeneous catalyst. The transformation proceeds efficiently at room temperature in an ethanol–water (1:1) medium, delivering excellent product yields (87–93%) within relatively short reaction times. The structural features of the prepared CoFe₂O₄ nanoparticles were confirmed by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR), verifying the formation of a crystalline inverse spinel phase with high purity. The catalyst was conveniently recovered using an external magnetic field and reused in five successive cycles without noticeable deterioration in catalytic performance. The developed protocol integrates environmental compatibility, catalyst recyclability, and procedural simplicity, providing a viable and ecoconscious alternative for the synthesis of pharmacologically relevant pyrazoline derivatives.

A.S.Salunkhe, V.S.Nalawade, P.P.Patil, R.N.Mahaldar, P.B. Piste,"Magnetically Recyclable CoFe₂O₄ Nanoparticles for Green Synthesis of 1,3,5-Trisubstituted-2-Pyrazolines" International Journal of Scientific Research and Engineering Development, V9(2): Page(748-751) Mar-Apr 2026. ISSN: 2581-7175. www.ijsred.com. Published by Scientific and Academic Research Publishing.