International Journal of Scientific Research and Engineering Development

Nanoparticles can help solve important issues related to traditional small molecules or bio macromolecules like DNA, RNA, and proteins used for diseases. They enable targeted delivery and can get past biological barriers. Recently silver nanoparticles have been used as delivery vehicles for therapeutic agents, such as anti-sense oligonucleotides and other small molecules. The toxicological evaluation of three common types of nanoparticles used in drug delivery. Metal, lipid and protein nanoparticles. It highlights the toxic effects associated with these nanoparticles. Metal based nanoparticles can increase oxidative stress and may enter the cell nucleus. Protein-based nanoparticles have been noted to cause liver and kidney toxicity. Nanoparticles are being used more in drug delivery, but there are rising concerns from regulatory authorities about their toxicity in living organisms.