International Journal of Scientific Research and Engineering Development

Transdermal drug delivery systems (TDDS) provide a non‑invasive and controlled method of administering therapeutic agents through the skin for systemic absorption. These adhesive patches bypass first‑pass metabolism and gastrointestinal degradation, thereby improving drug bioavailability and patient compliance. Structurally, TDDS consist of a backing layer, drug reservoir or matrix, adhesives, penetration enhancers, and release liners, all designed to regulate drug release and skin permeation. The stratum corneum serves as the primary barrier, with appendageal, transcellular, and intercellular pathways facilitating absorption. Various patch designs, including reservoir, matrix, and micro‑reservoir systems, have been developed to optimize release kinetics. Clinically, transdermal patches are widely applied in pain management, smoking cessation, cardiovascular therapy, and hormone replacement, while recent advances explore their potential for biologics. Despite challenges such as skin irritation, limited drug suitability, and patient variability, ongoing innovations in materials and formulation technologies continue to expand their therapeutic applications.

Mr.Roshan Datta Pawar, Megha. T. Salve, "Medical Patches for Transdermal Drug Delivery System" International Journal of Scientific Research and Engineering Development, V8(6): Page(2661-2674) Nov-Dec 2025. ISSN: 2581-7175. www.ijsred.com. Published by Scientific and Academic Research Publishing.