International Journal of Scientific Research and Engineering Development

Skin cancer remains a growing global health challenge, with its incidence expected to rise sharply in the coming decades if timely detection is not achieved. Although treatable in the early stages, significant obstacles persist, such as limited success in developing new therapeutic agents, clinical effectiveness, and the issue of drug resistance. To address these concerns, it is vital to gain deeper insight into the underlying causes of skin cancer, the mechanisms driving abnormal cell growth, and the factors that contribute to resistance against treatment. This article discusses the various forms of skin cancer and explores current treatment strategies, including phytocompounds, chemotherapy, radiotherapy, photothermal therapy, surgical interventions, and combination approaches, alongside molecular targets that influence cancer progression and metastasis. Furthermore, it highlights the promising role of nanotechnology in reducing disease severity particularly through the use of nanoparticles to combat drug resistance and provides an overview of relevant clinical trials.